Jordi Soriano's Lab
Jordi Soriano's Lab

Neuroscience: from physics to medicine

The list contains regular articles, books & book chapters and conference proceedings, all peer reviewed.



  • S. Faci, T. Lor, G. Ródenas, J.J. Mazo, J. Soriano and J. Gómez. "Dynamical robustness of collective neuronal activity upon targeted damage in interdependent networks", Eur. Phys. J. Spec. Top. (2022).
  • M. Angles, A. Hervera, J. Soriano, E. Marti, P. Carulla, F. Llorens, M. Nuvolone, A. Aguzzi, I. Ferrer, A. Gruart, J.M. Delgado and J.A. Del Río. "Analysis of co-isogenic prion protein deficient mice reveals behavioral deficits, learning impairment, and enhanced hippocampal excitability", BMC Biol. 20, 17 (2022).



  • G. Carola, D. Malagarriga, C. Calatayud, M. Pons, L. Blasco, Y. Richaud, I. Fernández, V. Baruffi, S. Beltramone, E. Molina, P. Dell'Era, J.J. Toledo, E. Tolosa, A.R. Muotri, J. García, J. Soriano, A. Raya and A. Consiglio. "Parkinson's disease patient-specific neuronal networks carrying the LRRK2 G2019S mutation unveil early functional alterations that predate neurodegeneration", Parkinson's Disease 7:55 (2021).
  • A. Koroleva, A. Deiwick, A. El-Tamer, L. Koch, Y. Shi, E. Estévez, A.A. Ludl, J. Soriano, D. Guseva, E. Ponimaskin and B. Chichkov. "In Vitro Development of Human iPSC-Derived Functional Neuronal Networks on Laser-Fabricated 3D Scaffolds", Appl. Mater. Interfaces 13, 7839-7853 (2021).
  • A. El-Tamer, A. Deiwick, L. Koch, J. Soriano, U. Hinze, B. Chichkov and A. Koroleva. "Development of in vitro 3D brain models on laser fabricated scaffolds", AMMM 10, 18416 (2021).
  • L. Hernández, S. Faci, J.G. Orlandi, U. Feudel, J. Gómez and J. Soriano. "Noise-driven amplification mechanisms governing the emergence of coherent extreme events in excitable systems", Physical Review Research 3, 023133 (2021).



  • S. Teller, E. Estévez, C. Granell, D. Tornero, J. Andilla, O.E. Olarte, P. Loza, A. Arenas and J. Soriano. "Spontaneous Functional Recovery after Focal Damage in Neuronal Cultures", ENEURO 7(1), 1-13 (2020).
  • E. Estévez, S. Teller, C. Granell, A. Arenas and J. Soriano. "Functional strengthening through synapticscaling upon connectivity disruption in neuronal cultures", Network Neuroscience 4(4), 1160-1180 (2020).
  • A. Alexander and J. Soriano. "Impact of Physical Obstacles on the Structural and Effective Connectivity of in silico Neuronal Circuits", Front. Comput. Neurosci. 14:77 (2020).
  • E. Tibau, A. Alexander, S. Rüdiger, J.G. Orlandi and J. Soriano. "Neuronal Spatial Arrangement Shapes Effective Connectivity Traits of in vitro Cortical Networks", IEEE TNSE 7(1) (2020).
  • J.A. Crowe, A. El-Tamer, D. Nagel, A.V. Koroleva, J. Madrid, O.E. Olarte, S. Sokolovsky, E. Estévez, A.A. Ludl, J. Soriano, P. Loza, B.N. Chichkov, E.J. Hill, H.R. Parri and E.U. Rafailov. "Development of two-photon polymerised scaffolds for optical interrogation and neurite guidance of human iPSC-derived cortical neuronal networks", Lab Chip 20, 1792-1806 (2020).
  • S. Fernández, J.G. Orlandi, G.A. García, M.J. Rodríguez, M. Masana, J. Soriano and J. Alberch. "Deficits in coordinated neuronal activity and network topology are striatal hallmarks in Huntington's disease", BMC Biology 18:58 (2020).
  • M. Gronning, C. Laterza, S. Palma, G. Kvist, E. Monni, O. Tsupykov, D. Tornero, N. Uoshima, J. Soriano, J. Bengzon, G. Martino, G. Skibo, O. Lindvall and Z. Kokaia. "Grafted human pluripotent stem cell-derived cortical neurons integrate into adult human cortical neural circuitry", STEM CELLS Transl. Med. 9, 1365-1377 (2020).
  • A. Comella, J.G. Orlandi, A. Miguez, M. Straccia, M. García, G. Bombau, M. Galofré, P. Sanders, J. Carrere, J.C. Segovia, J. Blasi, N.D. Allen, J. Alberch, J. Soriano and J.M. Canals. "Human Pluripotent Stem Cel.Derived Neurons Are Functionally Mature In Vitro and Integrate into the Mouse Striatum Following Transplantation", Mol Neurobiol 57, 2766-2798 (2020).



  • S. Faci, J. Soriano and J. Gómez. "Impact of targeted attack on the spontaneous activity in spatial and biologically-inspired neuronal networks", Chaos 29, 083126 (2019).
  • C. Calatayud, G. Carola, I. Fernández-Carasa, M. Valtorta, S. Jiménez, M. Díaz, J. Soriano, G. Cappelletti, J. García, A. Raya and A. Consiglio. "CRISPR/Cas9-mediated generation of a tyrosine hydroxylase reporter oPSC line for live imaging and isolation of dopaminergic neurons", Sci. Rep. 9:6811 (2019).
  • A. Domenico, G. Carola, C. Calatayud, M. Pons, J.P. Muñoz, Y. Richaud, I. Fernández, M. Gut, A. Faella, J. Parameswaran, J. Soriano, I. Ferrer, E. Tolosa, A. Zorzano, A.M. Cuervo, A. Raya and A. Consiglio. "Patiant-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease", Stem Cell Reports 12, 1-17 (2019).



  • E. Tibau and J. Soriano. "Analysis of spontaneous activity in neuronal cultures through recurrence plots: impact of varying connectivity", Eur. Phys. J. Spec. Top. 227, 999-1014 (2018).
  • H. Yamamoto, S. Moriya, K. Ide, T. Hayakawa, H. Akima, S. Sato, S. Kubota, T. Tanii, M. Niwano, S. Teller, J. Soriano and A. Hirano-Iwata. "Impact of modular organization on dynamical richness in cortical networks", Sci. Adv. 4: eaau4914 (2018).



  • V. Lemaire, D. Battaglia, I. Guyon, J. Soriano (Editors). "Neural Connectomics Challenge", Spriinger (2017).
  • L. Hernández, J.G. Orlandi, B. Cerruti, E. Vives and J. Soriano. "Dominance of Metric Correlations in Two-Dimensional Neuronal Cultures described through a Random Field Ising Model", Physical Review Letters 118, 208101 (2017).
  • G. García, A. Giralt, M. Anglada, N. Gaja, J.G. Orlandi, J. Soriano, J.M. Canals and J. Alberch. "7,8-dihidroxyflavone ameliorates cognitive and motor deficits in a Huntington's disease mouse model through specific activation of the PLCgamma1 pathway", Human Molecular genetics 26(16), 3144-3160 (2017).



  • J. Soriano and J. Casademunt. "Neuronal Cultures: Brain's complexity and Non-equilibrium Physics in a Dish". Contributions to Science 11, 225-235 (2016). OPEN ACCESS.

  • S. Teller and J. Soriano, "Experiments in clustered neuronal networks: A paradigm for complex modular dynamics", AIP Conf. Proc. (International Conference of Numerical Analysis and Applied Mathematics 2015), 1738, article 210015 (2016).



  • R. Fernández-Santiago, et al., “Aberrant epigenome in iPSC-derived dopaminergic neurons from Parkinson's disease patients”, EMBO Molecular Medicine 7, 1529-46 (2015). OPEN ACCESS.
  • S. Teller, I.B. Tahirbegi, M. Mir, J. Samitier, J. Soriano, “Magnetite-Amyloid-beta deteriorates activity and functional organization in an in vitro model for Alzheimer's disease”, Sci Rep 5, 17261 (2015). OPEN ACCESS.
  • I. Canals, J. Soriano, J.G. Orlandi, R. Torrent, Y. Richaud-Patin, S. Jiménez-Delgado, S. Merlin, A. Follenzi, A. Consiglio, L. Vilageliu. D. Grinberg, Á. Raya, “Activity and high-order effective connectivity alterations in Sanfilippo C patient-specific neuronal networks”, Stem Cell Reports 5, 1-12 (2015).
  • N. Fernàndez-Castillo, et al., “Transcriptomic and genetic studies identify NFAT5 as a candidate gene for cocaine dependence”, Translational Psychiatry 5, e667 (2015). OPEN ACCESS.
  • J. Soriano and I. Sendiña-Nadal. “Cultivos neuronales: sistema modelo para comprender la dinámica y la connectividad en redes ”, in 'Conectividad funcional y anatómica en el cerebro humano', capítulo 10, pp. 103-113, Elsevier (2015).
  • J.G. Orlandi, B. Ray, D. Battaglia, I. Guyon, V. Lemaire, M. Saeed, A. Statnikov, O. Stetter, J. Soriano, "First Connectomics Challenge: From Imaging to Connectivity", JMLR 46, 1-22 (2015). ACCESS



  • S. Teller, C. Granell, M. DeDomenico, J. Soriano, S. Gómez, A. Arenas, “Emergence of assortative mixing between clusters of cultured neurons”, PLoS Comput. Biol. 10, e1003796 (2014).
  • O. Stetter, J.G. Orlandi, J. Soriano, D. Battaglia, T. Geisel, “Transfer Entropy Reconstruction and Labeling of Neuronal Connections from Simulated Calcium Imaging”, PLoS One 9, e98842 (2014).
  • C. Schmeltzer, J. Soriano, I.M. Sokolov, S. Rüdiger, “Percolation of spatially constrained Erdös-Rényi networks with degree correlations”. Phys. Rev. E 89, 012116 (2014).
  • S. Teller, J. Soriano, "Dynamics in clustered neuronal cultures: a versatile experimental system for complex networks", Conference Proceedings (NDCN Workshop, Russia 2014).
  • I. Guyon, D. Battaglia, A. Guyon, V. Lemaire, J.G. Orlandi, M. Saeed, J. Soriano, A. Statnikov, O. Stetter, B. Ray, Design of the First Neuronal Connectomics Challenge: From Imaging to Connectivity", Conference Proceedings  (IEEE WCCI Congress, China 2014).



  • E. Tibau, M. Valencia, J. Soriano, “Identification of Neuronal Network Properties from the Spectral Analysis of Calcium Imaging Signals in Neuronal Cultures”, Front. Neur. Circ. 7, article 199 (2013).
  • J.G. Orlandi, J. Soriano, E. Álvarez-Lacalle, S. Teller, J. Casademunt, “Noise focusing and the emergence of coherent activity in neuronal cultures”. Nat. Physics 9, 582-590 (2013).
  • J. Orlandi, E. Álvarez-Lacalle, J. Soriano, J. Casademunt, "The emergence of spontaneous  activity in neuronal cultures", AIP Conf. Proc. (12th Granada Seminar) 1510, 25 (2013).
  • S. Teller, J. Soriano, "Experiments on Clustered Neuronal Networks", AIP Conf. Proc. (12th Granada Seminar) 1510, 244 (2013). 
  • E. Tibau, C. Bendiksen, S. Teller, N. Amigó, J. Soriano, "Activity-connectivity: Dynamics in Patterned Neuronal Cultures", AIP Conf. Proc. (12th Granada Seminar) 1510, 54 (2013).
  • O. Stetter, J. Soriano, T. Geisel, D. Battaglia, "From structure to function, via dynamics", AIP Conf. Proc. (12th Granada Seminar) 1510, 64 (2013).



  • O. Stetter, D. Battaglia, J. Soriano, T. Geisel, “Model-Free Reconstruction of Excitatory Neuronal Connectivity from Calcium Imaging Signals”. PLoS Comput. Biol. 8, e1002653 (2012).
  • D. Battaglia, J. Soriano, O.  Stetter, "Function follows dynamics, not (only) structure: from neural cultures to flexible information routing in the brain", Nonlinear Theory and Its Applications, IEICE Conference Proceedings 1, 551 (2012).
  • J.G. Orlandi, E. Álvarez-Lacalle, S. Teller, J. Casademunt, J. Soriano, "The role of connectivity and noise in the emergence of spontaneous activity in cultured neuronal networks", Nonlinear Theory and Its Applications, IEICE Conference Proceedings 1, 547(2012).



  • O. Cohen, A. Keselman, E. Moses, M. Rodríguez-Martínez, J. Soriano, T Tlusty, "Quorum Percolation: More is Different in Living Neural Networks", Europhys. Lett., 89, 18008 (2010).
  • S. Jacobi, J. Soriano, E. Moses. "BDNF and NT-3 increase velocity of activity front propagation in uni-dimensional hippocampal cultures", J. Neurophysiol. 104, 2932 (2010).
  • S. Jacobi, J. Soriano, M. Segal, E. Moses, "BDNF and NT-3 increase excitatory input connectivity in rat hippocampal cultures", Eur. J Neurosci. 30, 998 (2009).
  • J. Soriano, M. Rodríguez-Martínez, T. Tlusty, E. Moses. “Development of Input Connections in Neural Cultures”, PNAS 105, 13758-13763 (2008).
  • J. Soriano, I. Breskin, E. Moses, T. Tlusty, "Percolation approach to study connectivity in living neural networks", AIP Conf. Proc. (6th Granada Seminar) 887, 96 (2007).
  • J.-P. Eckman, O. Feinerman, L. Gruendlinger, E. Moses, J. Soriano, T. Tlusty, “The Physics of Living Neural Networks”, Phys. Rep. 449, 54-76 (2007).
  • I. Breskin, J. Soriano, E. Moses, T. Tlusty. “Percolation in Living Neural Networks”, Phys. Rev. Lett. 97, 188102 (2006).



  • J. Casademunt, J.G. Orlandi, J. Soriano, "Dinámica colectiva de las redes neuronales", Mente y Cerebro, Julio 2014. Link. PDF.
  • J. Soriano,"The problem of neuronal connectivity: how physicists can contribute to neuroscience", EL PAÍS, 2012. Link.
  • J. Soriano, "Das Gehirn als physikalische Größe", [The Brain for Physicists], FRANKFURTER ALLGEMEINE, 2011. Link.


Comments on our research

  • "Focus amdist the noise", J.M. Beggs, Nature Physics News and Views [Nat. Phys. 9, 533 (2013)]."